Risk Assessment and Clinical Management of Children and Adolescents with Heterozygous Familial Hypercholesterolaemia

Familial hypercholesterolaemia (FH) is a genetic and complex multifactorial lipid disorder, which increases the risk of premature atherosclerosis and coronary artery disease. FH is still underdiagnosed and undertreated globally and clinical strategies for the treatment and management of pediatric patients with this disorder are still far from being optimal. The objective of this position paper is to: (a) review the current approach and scientific background of cardiovascular (CV) risk stratification of children with FH, (b) to analyze available data on the clinical usefulness of other non-traditional cardiovascular risk factors as well as non-invasive methods of vascular phenotyping in children, and (c) to suggest some meaningful clinical recommendations on the potential integration of these data to help clinical-decision making and treatment planning of children with FH.

The Position Paper was written by 10 expert representatives of the three scientific societies (Associations of Preventive Pediatrics of Serbia, Mighty Medic, and the International Lipid Expert Panel.)